I think the first movie I saw her in was The Grifters, although imdb tells me she'd been in films and TV shows since the late-60s. She even appeared on Lavern and Shirley twice!
She's currently playing a kick-ass Broadway producer in the show Smash.
I love how in the show, she's clearly an older woman, but still strong, beautiful and happily, healthily sexual. She's what I hope being 61 is really like!
Keep kicking ass, Anjelica!